Dr. Ikotun is a translational imaging scientist with multidisciplinary training and expertise that spans inorganic chemistry, radiochemistry, molecular imaging, and immuno-oncology. She earned her Ph.D., in bioinorganic chemistry at Syracuse University where she investigated the magnetic and biological properties of pyrophosphate bridged bimetallic complexes. Her work was the first to evaluate the potent anti-cancer properties and conduct an in-depth investigation of the mechanism by which these pro-drugs elicit cell death. She went on to receive her training in nuclear imaging as a postdoctoral associate at Washington University School of Medicine. As an American Cancer Society Fellow, she developed diagnostic imaging agents that exploited the enhanced vitamin demand and overexpression of cell surface receptors to non-invasively detect cancerous lesions. Following her academic training, she worked as an industry scientist at Amgen Inc. and Bristol-Myers Squibb. During her six-year tenure in biotechnology/pharma she served as the subject matter expert for immuno-oncology and inflammation imaging and directly applied molecular imaging to drug discovery and development. This diverse experience has shaped her belief that molecular imaging has a key role to play in our understanding of disease biology, drug pharmacokinetics and pharmacodynamics, and is instrumental for elucidating the mechanisms of action of novel therapeutics in living subjects.

  • Ph.D.
  • 1. 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors. Mol Cancer Ther. 2024 Jun 04; 23(6):890-903.Chan AM, Olafsen T, Tsui J, Salazar FB, Aguirre B, Zettlitz KA, Condro M, Wu AM, Braun J, Gordon LK, Ashki N, Whitelegge J, Xu S, Ikotun O, Lee JT, Wadehra M.  PMID: 38417138.
  • 2. Local Delivery of OncoVEXmGM-CSF Generates Systemic Antitumor Immune Responses Enhanced by Cytotoxic T-Lymphocyte-Associated Protein Blockade. Clin Cancer Res. 2017 Oct 15; 23(20):6190-6202.Moesta AK, Cooke K, Piasecki J, Mitchell P, Rottman JB, Fitzgerald K, Zhan J, Yang B, Le T, Belmontes B, Ikotun OF, Merriam K, Glaus C, Ganley K, Cordover DH, Boden AM, Ponce R, Beers C, Beltran PJ.  PMID: 28706012.
  • 3. Evaluation of (89)Zr-pertuzumab in Breast cancer xenografts. Mol Pharm. 2014 Nov 03; 11(11):3988-95.Marquez BV, Ikotun OF, Zheleznyak A, Wright B, Hari-Raj A, Pierce RA, Lapi SE.  PMID: 25058168; PMCID: PMC4224522.
  • 4. Investigation of a vitamin B12 conjugate as a PET imaging probe. ChemMedChem. 2014 Jun; 9(6):1244-51.Ikotun OF, Marquez BV, Fazen CH, Kahkoska AR, Doyle RP, Lapi SE.  PMID: 24753453.
  • 5. Development of a Radiolabeled Irreversible Peptide Ligand for PET Imaging of Vascular Endothelial Growth Factor. J Nucl Med. 2014 Jun; 55(6):1029-34.Marquez BV, Ikotun OF, Parry JJ, Rogers BE, Meares CF, Lapi SE.  PMID: 24732153.
  • 6. Imaging of CD47 expression in xenograft and allograft tumor models. Mol Imaging. 2013 Nov-Dec; 12(8).Zheleznyak A, Ikotun OF, Dimitry J, Frazier WA, Lapi SE.  PMID: 24447619.
  • 7. Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET. PLoS One. 2013; 8(10):e77476.Ikotun OF, Marquez BV, Huang C, Masuko K, Daiji M, Masuko T, McConathy J, Lapi SE.  PMID: 24143237; PMCID: PMC3797081.
  • 8. The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86. Future Med Chem. 2011 Apr; 3(5):599-621.Ikotun OF, Lapi SE.  PMID: 21526898.