
Michael Van Dam
Department Vice Chair, Molecular and Medical Pharmacology Professor, Molecular and Medical Pharmacology
About
Dr. Van Dam received his Bachelor's degree in Engineering Physics from Queen’s University (Kingston, ON, Canada) and his Master's degree in Computer Engineering from the University of Toronto (Toronto, ON, Canada). He received his PhD in Applied Physics from the California Institute of Technology (Pasadena, CA, USA) where he studied under the direction of Prof. Stephen R. Quake in the area of microfluidics. Afterwards, he completed a Postdoc position at Caltech under the direction of Prof. James R. Heath on microfluidics applied to the synthesis of radiopharmaceuticals, and transitioned to a Senior Scientist role at Siemens Molecular Imaging Biomarker Research (Culver City, CA, USA) to commercialize this work. He joined the UCLA Department of Molecular & Medical Pharmacology in 2007. He is currently a Professor in the Crump Institute for Molecular Imaging, Department of Molecular & Medical Pharmacology, Department of Bioengineering, and the Physics and Biology in Medicine Graduate Program, as well as a Vice Chair of the Department of Molecular & Medical Pharmacology and a Co-Associate Director of the Crump Institute for Molecular Imaging. His research currently focuses on the development of novel, miniaturized technologies to perform multi-step radiosynthesis of radiopharmaceuticals (e.g. PET imaging tracers, theranostic agents), high-sensitivity radiochemical analysis, and instruments and methods for high-throughput radiochemical synthesis and analysis (with applications in synthesis optimization and novel radiopharmaceutical development). He has published over 70 papers and multiple book chapters, and has been granted over 20 patents, related to these discoveries. Dr. van Dam is also a co-founder of Sofie, Inc., which has commercialized a flexible radiosynthesizer technology and intuitive unit-operation-based programming approach developed in his laboratory (ELIXYS FLEX/CHEM and PURE/FORM).
Education and Degree(s)
- Ph.D
Publications
- Scalable droplet-based radiosynthesis of [18F]fluorobenzyltriphenylphosphonium cation ([18F]FBnTP) via a "numbering up" approach. Lab Chip. 2024 02 13; 24(4):728-737.Lu Y, Collins J, Lin KS, van Dam RM. PMID: 38240629; PMCID: PMC10869106.
- Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysis via radio-TLC. Anal Methods. 2023 01 19; 15(3):377-387.Laferriere-Holloway TS, Rios A, van Dam RM. PMID: 36542448; PMCID: PMC9891729.
- Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry. Sci Rep. 2022 06 17; 12(1):10263.Rios A, Holloway TS, Chao PH, De Caro C, Okoro CC, van Dam RM. PMID: 35715457; PMCID: PMC9205965.
- Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharm Chem. 2022 Apr 26; 7(1):9.Bernardes E, Caravan P, van Dam RM, Deuther-Conrad W, Ellis B, Furumoto S, Guillet B, Huang YY, Jia H, Laverman P, Li Z, Liu Z, Lodi F, Miao Y, Perk L, Schirrmacher R, Vercoullie J, Yang H, Yang M, Yang X, Zhang J, Zhang MR, Zhu H. PMID: 35471681; PMCID: PMC9043146.
- Economical Production of Radiopharmaceuticals for Preclinical Imaging Using Microdroplet Radiochemistry. Methods Mol Biol. 2022; 2393:813-828.Wang J, van Dam RM. PMID: 34837213.
- Economical droplet-based microfluidic production of [18F]FET and [18F]Florbetaben suitable for human use. Sci Rep. 2021 10 19; 11(1):20636.Lisova K, Wang J, Hajagos TJ, Lu Y, Hsiao A, Elizarov A, van Dam RM. PMID: 34667246; PMCID: PMC8526601.