Jennifer Murphy

About

Professor Murphy received her B.S. degree in chemistry (cum laude) from Santa Clara University in Northern California. She obtained her Ph.D. in 2011 from UCLA where she worked under the direction of Michael E. Jung on natural product total synthesis. She transitioned to the David Geffen School of Medicine where she was a Scholar in Oncologic Molecular Imaging (SOMI) postdoctoral fellow in the Ahmanson Translational Imaging Division at UCLA. In 2012, Prof. Murphy joined Tobias Ritter's research laboratory at Harvard University as a visiting scholar. In 2013, she joined the UCLA faculty at the Crump Institute for Molecular Imaging as an Assistant Professor in the Department of Molecular and Medical Pharmacology. Prof. Murphy is on the Journal of Nuclear Medicine editorial board and is a member of the Jonsson Comprehensive Cancer Center at UCLA. She was elected to the Board of Directors for the International Society of Radiopharmaceutical Sciences (ISRS) and is a Scientific Advisory Board Member for the Carbon and Fluorine Radio Chemistry (CAFACHEM) Program. In 2019, Prof. Murphy was honored with the "Ones to Watch: Early Career Professionals Making a Difference" award by the Society of Nuclear Medicine & Molecular Imaging (SNMMI).

Education and Degree(s)

B.S. degree in chemistry (cum laude) from Santa Clara University in Northern California.
Ph.D. in 2011 from UCLA.

Publications

1. 18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma. Chem Sci. 2023 Dec 06; 14(47):13825-13831.Narayanam MK, Tsang JE, Xu S, Nathanson DA, Murphy JM. PMID: 38075671; PMCID: PMC10699577.
2. Deoxyfluorination of phenols for chemoselective 18F-labeling of peptides. Nat Protoc. 2023 Nov; 18(11):3614-3651.Halder R, Ma G, Rickmeier J, McDaniel JW, Petzold R, Neumann CN, Murphy JM, Ritter T. PMID: 37853158.
3. An Organometallic Gold(III) Reagent for 18F Labeling of Unprotected Peptides and Sugars in Aqueous Media. Org Lett. 2022 07 22; 24(28):5132-5136.McDaniel JW, Stauber JM, Doud EA, Spokoyny AM, Murphy JM. PMID: 35802398; PMCID: PMC9573800.
4. Positron Emission Tomography Tracer Design of Targeted Synthetic Peptides via 18F-Sydnone Alkyne Cycloaddition. Bioconjug Chem. 2021 Sep 15; 32(9):2073-2082.Narayanam MK, Lai BT, Loredo JM, Wilson JA, Eliasen AM, LaBerge NA, Nason M, Cantu AL, Luton BK, Xu S, Agnew HD, Murphy JM. PMID: 34415731.
5. One-Step Synthesis of [18F]Fluoro-4-(vinylsulfonyl)benzene: A Thiol Reactive Synthon for Selective Radiofluorination of Peptides. Org Lett. 2021 01 15; 23(2):530-534.Ma G, McDaniel JW, Murphy JM. PMID: 33373261.
6. Rapid One-Step 18F-Labeling of Peptides via Heteroaromatic Silicon-Fluoride Acceptors. Org Lett. 2020 02 07; 22(3):804-808.Narayanam MK, Toutov AA, Murphy JM. PMID: 31927933.
7. Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging. Chem Sci. 2020 Jan 07; 11(7):1832-1838.Gamache RF, Zettlitz KA, Tsai WK, Collins J, Wu AM, Murphy JM. PMID: 34123276; PMCID: PMC8148382.
8. A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging. J Nucl Med. 2019 10; 60(10):1467-1473.Zettlitz KA, Waldmann CM, Tsai WK, Tavaré R, Collins J, Murphy JM, Wu AM. PMID: 30877181; PMCID: PMC6785789.
9. Automated concentration of [18F]fluoride into microliter volumes. Appl Radiat Isot. 2018 Nov; 141:138-148.Chao PH, Lazari M, Hanet S, Narayanam MK, Murphy JM, van Dam RM. PMID: 30243135; PMCID: PMC6502507.
10. Origins of halogen effects in bioorthogonal sydnone cycloadditions. Chem Commun (Camb). 2018 May 15; 54(40):5082-5085.Tao H, Liu F, Zeng R, Shao Z, Zou L, Cao Y, Murphy JM, Houk KN, Liang Y. PMID: 29707720; PMCID: PMC5953849.
11. Readily Accessible Ambiphilic Cyclopentadienes for Bioorthogonal Labeling. J Am Chem Soc. 2018 05 23; 140(20):6426-6431.Levandowski BJ, Gamache RF, Murphy JM, Houk KN. PMID: 29712423; PMCID: PMC6314806.
12. Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11309-11314.Collins J, Waldmann CM, Drake C, Slavik R, Ha NS, Sergeev M, Lazari M, Shen B, Chin FT, Moore M, Sadeghi S, Phelps ME, Murphy JM, van Dam RM. PMID: 29073049; PMCID: PMC5664529.
13. Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones. Angew Chem Int Ed Engl. 2017 10 09; 56(42):13006-13010.Narayanam MK, Ma G, Champagne PA, Houk KN, Murphy JM. PMID: 28834065; PMCID: PMC5674999.
14. Copper-Mediated Oxidative Fluorination of Aryl Stannanes with Fluoride. Org Lett. 2016 09 16; 18(18):4522-5.Gamache RF, Waldmann C, Murphy JM. PMID: 27571319.
15. A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Organometallics. 2016 Apr 11; 35(7):1008-1014.Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. PMID: 27087736; PMCID: PMC4829938.
16. Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. Chem Sci. 2016 Feb 01; 7(2):1257-1261.Narayanam MK, Liang Y, Houk KN, Murphy JM. PMID: 29910881; PMCID: PMC4763938.
17. Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer. Appl Radiat Isot. 2015 Sep; 103:9-14.Lazari M, Lyashchenko SK, Burnazi EM, Lewis JS, van Dam RM, Murphy JM. PMID: 26046518; PMCID: PMC4530021.
18. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10; 211(3):473-86.Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. PMID: 24567448; PMCID: PMC3949575.
19. Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules. Acta Crystallogr D Biol Crystallogr. 2014 Jan; 70(Pt 1):68-78.Nomme J, Murphy JM, Su Y, Sansone ND, Armijo AL, Olson ST, Radu C, Lavie A. PMID: 24419380; PMCID: PMC3919262.
20. Palladium(III)-catalyzed fluorination of arylboronic acid derivatives. J Am Chem Soc. 2013 Sep 25; 135(38):14012-5.Mazzotti AR, Campbell MG, Tang P, Murphy JM, Ritter T. PMID: 24040932; PMCID: PMC3820116.
21. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708.Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. PMID: 23947754; PMCID: PMC3789385.

Membership and Service

Member, Jonsson Comprehensive Cancer Center
Member, PBM Interdepartmental Graduate Program
Mentor, Chemistry-Biology Interface Research Training Program