Dr. Hsian-Rong (HR) Tseng is currently a Professor in the Department of Molecular & Medical Pharmacology in David Geffen School of Medicine at UCLA. He also holds memberships in the California NanoSystems Institute, Crump Institute for Molecular Imaging, and Jonsson Comprehensive Cancer Center on the UCLA campus. Dr. Tseng has over 34 years of experience in organic chemistry, covering synthetic methodology, organometallic, supramolecular and radiochemistry, as well as 24 years of experience in micro- and nanofabrication for applications in biomedical devices. To translate liquid biopsy-based diagnostic technologies into the clinical setting, he has established an extensive collaboration network with oncology programs at UCLA and Cedars Sinai Medical Center, and other medical institutions in the US. To facilitate the commercial transition of in vitro diagnostics, he founded CytoLumina Technologies Corp. and Eximius Diagnostics. The NanoVelcro Chips, a product of CytoLumina, were recognized as a Success Story by the National Cancer Institute's Innovative Molecular Analysis Technologies program in October 2019. In December 2022, the FDA awarded Breakthrough Device Designation to the Liver Cancer Test developed by Eximius Dx, a step that will fast-track its FDA approval process.

  • Ph.D

 


 

  • B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer. Drug Resist Updat. 2025 Mar; 79:101207.Ju Y, Watson J, Wang JJ, Yen YT, Gevorkian L, Chen Z, Tu KH, Salumbides B, Phung A, Zhao C, Kim H, Ji YR, Zhang RY, Lee J, Gong J, Scher K, You S, Chen JF, Tseng HR, Zhu Y, Posadas EM.  PMID: 39914189.
  • Liquid biopsy in hepatocellular carcinoma: Challenges, advances, and clinical implications. Clin Mol Hepatol. 2025 Feb; 31(Suppl):S255-S284.Park J, Lee YT, Agopian VG, Liu JS, Koltsova EK, You S, Zhu Y, Tseng HR, Yang JD.  PMID: 39604328; PMCID: PMC11925447.
  • Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer. Drug Resist Updat. 2024 Sep; 76:101117.Xie Z, Wang Y, Chen T, Fan W, Wei L, Liu B, Situ X, Zhan Q, Fu T, Tian T, Li S, He Q, Zhou J, Wang H, Du J, Tseng HR, Lei Y, Tang KJ, Ke Z.  PMID: 38996549.
  • High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester†. Biol Reprod. 2024 May 09; 110(5):936-949.Gonzalez TL, Wertheimer S, Flowers AE, Wang Y, Santiskulvong C, Clark EL, Jefferies CA, Lawrenson K, Chan JL, Joshi NV, Zhu Y, Tseng HR, Karumanchi SA, Williams Iii J, Pisarska MD.  PMID: 38271627; PMCID: PMC11094392.
  • Author Correction: Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer. Nat Commun. 2024 May 01; 15(1):3693.Stackpole ML, Zeng W, Li S, Liu CC, Zhou Y, He S, Yeh A, Wang Z, Sun F, Li Q, Yuan Z, Yildirim A, Chen PJ, Winograd P, Tran B, Lee YT, Li PS, Noor Z, Yokomizo M, Ahuja P, Zhu Y, Tseng HR, Tomlinson JS, Garon E, French S, Magyar CE, Dry S, Lajonchere C, Geschwind D, Choi G, Saab S, Alber F, Wong WH, Dubinett SM, Aberle DR, Agopian V, Han SB, Ni X, Li W, Zhou XJ.  PMID: 38693151; PMCID: PMC11063198.
  • Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block. Hepatology. 2024 10 01; 80(4):763-765.Lee YT, Tseng HR, Yang JD.  PMID: 38640021.